research assistant

Applications are invited for a Research Associate position available in the laboratory of Prof. Luca Pellegrini in the Department of Biochemistry of the University of Cambridge, UK.

Work in the laboratory is focused on elucidating the structural basis for eukaryotic DNA replication (Rzechorzek et al, NAR, 2020; Evrin et al, EMBOJ, 2018; Villa et al, Mol Cell, 2016; Simon et al, Nat Comm, 2016; Simon et al, Nature, 2014) and associated DNA repair processes (Lerner et al, EMBOJ, 2020; Brouwer et al, EMBOJ, 2018).

The aim of the project is to elucidate key molecular mechanisms of DNA synthesis and repair by the human replisome, the dynamic multi-protein ensemble responsible for duplicating chromosomal DNA before cell division. To achieve this goal, the successful candidate will use a multi-disciplinary approach that includes preparative biochemistry of multi-protein complexes, protein engineering and state-of-the-art biophysical and structural techniques.

The project will advance our understanding of how our cells copy their DNA and thus maintain genomic stability across cellular generations. In addition to its biological importance, such information will have great medical relevance, as disease such as cancer and premature aging are promoted by errors in our genome caused by defective replication.

Applicants will hold or be about to receive a PhD in a relevant subject. They must have a track record in conducting internationally competitive research, including peer reviewed publications as first author. The ideal candidate will combine an ability to work independently and to fit in well in a team. Above all, she/he will be enthusiastic about pursuing fundamental research and be highly motivated to succeed professionally.

Expert knowledge of biochemical methods for production of recombinant multi-protein assemblies and their quantitative biophysical analysis is highly preferred. The position would also be suitable for a cell biologist with expertise of CRISPR technologies and interested in applying her/his skills to Structural Biology. No prior knowledge of cryoEM methods is required as training will be available.

Fixed-term: The funds for this post are available until 31 May 2026 in the first instance.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Informal enquiries can be sent to Professor Pellegrini: lp212@cam.ac.uk

For any questions about this vacancy or the application process please contact: personnel@bioc.cam.ac.uk

Please quote reference PH37138 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.