Postdoctoral Research Fellow

UE07: £35,333.00 - £42,155.00 Per Annum.

College of Medicine and Veterinary Medicine / School of Molecular, Genetic and Population Health Sciences / Institute of Genetics and Cancer.

Fixed Term Contract - 3 years from April 2023 (later start date can be considered); Full Time - 35 Hours Per Week.

We are looking for a Postdoctoral Research Fellow.

The Opportunity:

The Wilkinson laboratory seeks a Postdoctoral Research Fellow. This post is available from April 2023 for three years (salary of £35,333-£42,155, dependent upon experience).

Selective autophagy of the endoplasmic reticulum (ER-phagy) is emerging as a fundamental pathway in maintenance of cellular health. Furthermore, our laboratory has identified aberrations in ER-phagy during formation and progression of cancer. However, our view of the molecular composition and function(s) of the ER-phagy pathway is incomplete, especially in physiologically relevant settings.

We have recently completed a comprehensive integrated proteomic and genetic screen for novel facilitators of ER-phagy. Using cutting-edge cell biological, biochemical and omics techniques, the candidate will uncover the mechanism of action of these molecules and their role in integrating control of ER-phagy with other cellular phenomena such as proteasomal and transcriptional regulation of ER homeostasis.

Overall, the work will contribute to a larger, high-quality program of research designed to address the mechanisms and functions of ER-phagy, hosted within a dynamic laboratory at the forefront of this field.

References

Smith, M et al (2018). CCPG1 Is a Non-canonical Autophagy Cargo Receptor Essential for ER-Phagy and Pancreatic ER Proteostasis. Developmental Cell . doi.org/10.1016/j.devcel.2017.11.024

Wilkinson, S (2019). Emerging principles of selective ER autophagy. Journal of Molecular Biology. doi.org/10.1111/febs.14932

Informal enquiries can be directed to Simon Wilkinson, s.wilkinson@ed.ac.uk

Your skills and attributes for success:

• Excellent wet lab skills (cell, molecular biology and/or biochemistry).
• Knowledge of autophagy.
• Creativity.
• Eye for detail.
• Keen problem solving skills.

Click to view a copy of the full job description

As a valued member of our team you can expect:

An exciting, positive, creative, challenging and rewarding place to work. We give you support, nurture your talent and reward success. You will benefit from a competitive reward package and a wide range of staff benefits, which includes a generous holiday entitlement, a defined benefits pension scheme , staff discounts, family friendly initiatives , flexible working and much more. Access our staff benefits page for further information and use our reward calculator to find out the total value of pay and benefits provided.

The University of Edinburgh holds a Silver Athena SWAN award in recognition of our commitment to advance gender equality in higher education. We are members of the Race Equality Charter and we are also Stonewall Scotland Diversity Champions, actively promoting LGBT equality.

If invited for interview you will be required to evidence your right to work in the UK. Further information is available on our right to work webpages.

The University is able to sponsor the employment of international workers in this role. If successful, an international applicant requiring sponsorship to work in the UK will need to satisfy the UK Home Office’s English Language requirements and apply for and secure a Skilled Worker Visa.

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